1NOW

Human lysosomal beta-hexosaminidase isoform B in complex with (2R,3R,4S,5R)-2-Acetamido-3,4-Dihydroxy-5-Hydroxymethyl-Piperidinium Chloride (GalNAc-isofagomine)

1NOW の概要

• エントリーDOI: 10.2210/pdb1now/pdb
• 関連するPDBエントリー: 1NOU
• 分子名称: beta-hexosaminidase beta chain, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, (2R,3R,4S,5R)-2-ACETAMIDO-3,4-DIHYDROXY-5-HYDROXYMETHYL-PIPERIDINE, ... (6 entities in total)
• 機能のキーワード: (beta/alpha)8-barrel, homodimer, family 20 glycosidase, hydrolase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 117999.35

構造登録者

Mark, B.L.,Mahuran, D.J.,Cherney, M.M.,Zhao, D.,Knapp, S.,James, M.N.G. (登録日: 2003-01-16, 公開日: 2003-04-29, 最終更新日: 2020-07-29)

• 主引用文献: Mark, B.L.,Mahuran, D.J.,Cherney, M.M.,Zhao, D.,Knapp, S.,James, M.N.G.; Crystal structure of Human beta-hexosaminidase B: Understanding the molecular basis of Sandhoff and Tay-Sachs disease; J.Mol.Biol., 327:1093-1109, 2003; PubMed: 12662933; DOI: 10.1016/S0022-2836(03)00216-X

実験手法

X-RAY DIFFRACTION (2.2 Å)