1NOB

KNOB DOMAIN FROM ADENOVIRUS SEROTYPE 12

1NOB の概要

• エントリーDOI: 10.2210/pdb1nob/pdb
• 関連するPDBエントリー: 1KAC
• 分子名称: PROTEIN (FIBER KNOB PROTEIN) (1 entity in total)
• 機能のキーワード: receptor binding, viral protein
• 由来する生物種: Human adenovirus 12
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 119666.86

構造登録者

Bewley, M.C.,Springer, K.,Zhang, Y.B.,Freimuth, P.,Flanagan, J.M. (登録日: 1999-05-05, 公開日: 1999-11-24, 最終更新日: 2023-08-16)

主引用文献

Bewley, M.C.,Springer, K.,Zhang, Y.B.,Freimuth, P.,Flanagan, J.M.
Structural analysis of the mechanism of adenovirus binding to its human cellular receptor, CAR.
Science, 286:1579-1583, 1999

PubMed Abstract: Binding of virus particles to specific host cell surface receptors is known to be an obligatory step in infection even though the molecular basis for these interactions is not well characterized. The crystal structure of the adenovirus fiber knob domain in complex with domain I of its human cellular receptor, coxsackie and adenovirus receptor (CAR), is presented here. Surface-exposed loops on knob contact one face of CAR, forming a high-affinity complex. Topology mismatches between interacting surfaces create interfacial solvent-filled cavities and channels that may be targets for antiviral drug therapy. The structure identifies key determinants of binding specificity, which may suggest ways to modify the tropism of adenovirus-based gene therapy vectors.

PubMed: 10567268
DOI: 10.1126/science.286.5444.1579

実験手法

X-RAY DIFFRACTION (2.6 Å)