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1NM8

Structure of Human Carnitine Acetyltransferase: Molecular Basis for Fatty Acyl Transfer

1NM8 の概要
エントリーDOI10.2210/pdb1nm8/pdb
分子名称Carnitine O-acetyltransferase (2 entities in total)
機能のキーワードtwo equally sized domains, anti-parallel beta-strand, transferase
由来する生物種Homo sapiens (human)
細胞内の位置Endoplasmic reticulum (Potential). Isoform 1: Mitochondrion (Potential). Isoform 2: Peroxisome (Potential): P43155
タンパク質・核酸の鎖数1
化学式量合計69902.87
構造登録者
Wu, D.,Govindasamy, L.,Lian, W.,Gu, Y.,Kukar, T.,Agbandje-McKenna, M.,McKenna, R. (登録日: 2003-01-09, 公開日: 2003-03-11, 最終更新日: 2024-02-14)
主引用文献Wu, D.,Govindasamy, L.,Lian, W.,Gu, Y.,Kukar, T.,Agbandje-McKenna, M.,McKenna, R.
Structure of Human Carnitine Acetyltransferase. Molecular Basis for Fatty Acyl Transfer
J.Biol.Chem., 278:13159-13165, 2003
Cited by
PubMed Abstract: Carnitine acyltransferases are a family of ubiquitous enzymes that play a pivotal role in cellular energy metabolism. We report here the x-ray structure of human carnitine acetyltransferase to a 1.6-A resolution. This structure reveals a monomeric protein of two equally sized alpha/beta domains. Each domain is shown to have a partially similar fold to other known but oligomeric enzymes that are also involved in group-transfer reactions. The unique monomeric arrangement of the two domains constitutes a central narrow active site tunnel, indicating a likely universal feature for all members of the carnitine acyltransferase family. Superimposition of the substrate complex of a related protein, dihydrolipoyl trans-acetylase, reveals that both substrates localize to the active site tunnel of human carnitine acetyltransferase, suggesting the location of the ligand binding sites for carnitine and coenzyme A. Most significantly, this structure provides critical insights into the molecular basis for fatty acyl chain transfer and a possible common mechanism among a wide range of acyltransferases utilizing a catalytic dyad.
PubMed: 12562770
DOI: 10.1074/jbc.M212356200
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (1.6 Å)
構造検証レポート
Validation report summary of 1nm8
検証レポート(詳細版)ダウンロードをダウンロード

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件を2025-07-09に公開中

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