1NLP
STRUCTURE OF SIGNAL TRANSDUCTION PROTEIN, NMR, MINIMIZED AVERAGE STRUCTURE
Summary for 1NLP
| Entry DOI | 10.2210/pdb1nlp/pdb |
| Descriptor | C-SRC, NL2 (MN8-MN1-PLPPLP) (2 entities in total) |
| Functional Keywords | src, sh3 domain, ligands, non-peptide elements, complex (transferase-peptide), complex (transferase-peptide) complex, complex (transferase/peptide) |
| Biological source | Gallus gallus (chicken) |
| Total number of polymer chains | 2 |
| Total formula weight | 8157.10 |
| Authors | Feng, S.,Kapoor, T.M.,Shirai, F.,Combs, A.P.,Schreiber, S.L. (deposition date: 1996-08-04, release date: 1997-01-27, Last modification date: 2024-10-23) |
| Primary citation | Feng, S.,Kapoor, T.M.,Shirai, F.,Combs, A.P.,Schreiber, S.L. Molecular basis for the binding of SH3 ligands with non-peptide elements identified by combinatorial synthesis. Chem.Biol., 3:661-670, 1996 Cited by PubMed Abstract: Protein-structure-based combinatorial chemistry has recently been used to discover several ligands containing non-peptide binding elements to the Src SH3 domain. The encoded library used has the form Cap-M1-M2-M3-PLPPLP, in which the Cap and Mi's are composed of a diverse set of organic monomers. The PLPPLP portion provided a structural bias directing the non-peptide fragment Cap-M1-M2-M3 to the SH3 specificity pocket. Fifteen ligands were selected from > 1.1 million distinct compounds. The structural basis for selection was unknown. PubMed: 8807900DOI: 10.1016/S1074-5521(96)90134-9 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
Download full validation report
