1NLO

STRUCTURE OF SIGNAL TRANSDUCTION PROTEIN, NMR, MINIMIZED AVERAGE STRUCTURE

Summary for 1NLO

• Entry DOI: 10.2210/pdb1nlo/pdb
• Descriptor: C-SRC, NL1 (MN7-MN2-MN1-PLPPLP) (2 entities in total)
• Functional Keywords: src, sh3 domain, ligands, non-peptide elements, complex (transferase-peptide), complex (transferase-peptide) complex, complex (transferase/peptide)
• Biological source: Gallus gallus (chicken)
• Total number of polymer chains: 2
• Total formula weight: 8253.23

Authors

Feng, S.,Kapoor, T.M.,Shirai, F.,Combs, A.P.,Schreiber, S.L. (deposition date: 1996-08-04, release date: 1997-01-27, Last modification date: 2024-10-23)

Primary citation

Feng, S.,Kapoor, T.M.,Shirai, F.,Combs, A.P.,Schreiber, S.L.
Molecular basis for the binding of SH3 ligands with non-peptide elements identified by combinatorial synthesis.
Chem.Biol., 3:661-670, 1996

PubMed Abstract: Protein-structure-based combinatorial chemistry has recently been used to discover several ligands containing non-peptide binding elements to the Src SH3 domain. The encoded library used has the form Cap-M1-M2-M3-PLPPLP, in which the Cap and Mi's are composed of a diverse set of organic monomers. The PLPPLP portion provided a structural bias directing the non-peptide fragment Cap-M1-M2-M3 to the SH3 specificity pocket. Fifteen ligands were selected from > 1.1 million distinct compounds. The structural basis for selection was unknown.

PubMed: 8807900
DOI: 10.1016/S1074-5521(96)90134-9

Experimental method

SOLUTION NMR