1NL6

Crystal Structure Of The Cysteine Protease Human Cathepsin K In Complex With A Covalent Azepanone Inhibitor

1NL6 の概要

• エントリーDOI: 10.2210/pdb1nl6/pdb
• 関連するPDBエントリー: 1ATK 1AU0 1AU2 1AU3 1AU4
• 分子名称: Cathepsin K, 5-(2-MORPHOLIN-4-YLETHOXY)BENZOFURAN-2-CARBOXYLIC ACID ((S)-3-METHYL-1-{(S)-3-OXO-1-[2-(3-PYRIDIN-2-YLPHENYL)ACETYL]AZEPAN-4-YLCARBAMOYL}BUTYL)AMIDE (2 entities in total)
• 機能のキーワード: hydrolase, sulfhydryl proteinase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Lysosome: P43235
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 48466.62

構造登録者

Smith, W.W.,Janson, C.A.,Zhao, B. (登録日: 2003-01-06, 公開日: 2003-01-14, 最終更新日: 2023-08-16)

• 主引用文献: Marquis, R.W.,Ru, Y.,LoCastro, S.M.,Zeng, J.,Yamashita, D.S.,Oh, H.J.,Erhard, K.F.,Davis, L.D.,Tomaszek, T.A.,Tew, D.,Salyers, K.,Proksch, J.,Ward, K.,Smith, B.,Levy, M.,Cummings, M.D.,Haltiwanger, R.C.,Trescher, G.,Wang, B.,Hemling, M.E.,Quinn, C.J.,Cheng, H.-Y.,Lin, F.,Smith, W.W.,Janson, C.A.,Zhao, B.,McQueney, M.S.,D'Alessio, K.,Lee, C.P.,Marzulli, A.,A Dodds, R.,Blake, S.,Hwang, S.M.,James, I.E.,Gress, C.J.,Bradley, B.R.,Lark, M.W.,Gowen, M.,Veber, D.F.; Azepanone-based inhibitors of human and rat cathepsin K; J.Med.Chem., 44:1380-1395, 2001; PubMed: 11311061; DOI: 10.1021/jm000481x

実験手法

X-RAY DIFFRACTION (2.8 Å)