1NKW

Crystal Structure Of The Large Ribosomal Subunit From Deinococcus Radiodurans

「1LNR」から置き換えられました 「1KC9」から置き換えられました 「1KPJ」から置き換えられました

1NKW の概要

• エントリーDOI: 10.2210/pdb1nkw/pdb
• 関連するPDBエントリー: 1JZX 1JZY 1JZZ 1K00 1K01 1NJM 1NJN 1NJO 1NJP
• 分子名称: 23S ribosomal RNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ... (31 entities in total)
• 機能のキーワード: ribosome; large subunit; 50s; deinococcus radiodurans; x-ray structure; peptidyl-transferase, peptide bond formation, ribosome
• 由来する生物種: Deinococcus radiodurans; 詳細
• タンパク質・核酸の鎖数: 31
• 化学式量合計: 1388100.24

構造登録者

Harms, J.M.,Schluenzen, F.,Zarivach, R.,Bashan, A.,Gat, S.,Agmon, I.,Bartels, H.,Franceschi, F.,Yonath, A. (登録日: 2003-01-05, 公開日: 2003-02-11, 最終更新日: 2023-08-16)

主引用文献

Harms, J.M.,Schluenzen, F.,Zarivach, R.,Bashan, A.,Gat, S.,Agmon, I.,Bartels, H.,Franceschi, F.,Yonath, A.
High resolution structure of the large ribosomal subunit from a mesophilic eubacterium
Cell(Cambridge,Mass.), 107:679-688, 2001

PubMed Abstract: We describe the high resolution structure of the large ribosomal subunit from Deinococcus radiodurans (D50S), a gram-positive mesophile suitable for binding of antibiotics and functionally relevant ligands. The over-all structure of D50S is similar to that from the archae bacterium Haloarcula marismortui (H50S); however, a detailed comparison revealed significant differences, for example, in the orientation of nucleotides in peptidyl transferase center and in the structures of many ribosomal proteins. Analysis of ribosomal features involved in dynamic aspects of protein biosynthesis that are partially or fully disordered in H50S revealed the conformations of intersubunit bridges in unbound subunits, suggesting how they may change upon subunit association and how movements of the L1-stalk may facilitate the exit of tRNA.

PubMed: 11733066
DOI: 10.1016/S0092-8674(01)00546-3

実験手法

X-RAY DIFFRACTION (3.1 Å)