1NIH

Structure of deoxy-quaternary haemoglobin with liganded beta subunits

1NIH の概要

• エントリーDOI: 10.2210/pdb1nih/pdb
• 分子名称: HEMOGLOBIN (NICKELOUS DEOXY) (ALPHA CHAIN), HEMOGLOBIN (FERROUS CARBONMONOXY) (BETA CHAIN), PROTOPORPHYRIN IX CONTAINING NI(II), ... (7 entities in total)
• 機能のキーワード: oxygen transport
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 65268.80

構造登録者

Luisi, B.,Liddington, B. (登録日: 1990-03-14, 公開日: 1992-10-15, 最終更新日: 2024-02-14)

主引用文献

Luisi, B.,Liddington, B.,Fermi, G.,Shibayama, N.
Structure of deoxy-quaternary haemoglobin with liganded beta subunits.
J.Mol.Biol., 214:7-14, 1990

PubMed Abstract: We have determined the structure of a T-state haemoglobin in which the haem groups of the beta subunits have carbon monoxide bound, and the alpha subunits have nickel replacing the haem iron and are ligand-free. The structural adjustments on binding ligand in the T state are in the same direction as those associated with the quaternary transition, and a translational shift of the haem is severely restricted. We explain how these observations may account for the low ligand affinity of the beta haem of T-state haemoglobin.

PubMed: 2370669
DOI: 10.1016/0022-2836(90)90139-D

実験手法

X-RAY DIFFRACTION (2.6 Å)