1NI1

Imidazole and cyanophenyl farnesyl transferase inhibitors

Summary for 1NI1

Related1N9A 1N95
DescriptorProtein farnesyltransferase alpha subunit, Protein farnesyltransferase beta subunit, ZINC ION, ... (5 entities in total)
Functional Keywordstransferase, prenyltransferase, ftase, cyanophenyl
Biological sourceRattus norvegicus (Norway rat)
Total number of polymer chains2
Total molecular weight83841.27
Authors
Tong, Y.,Lin, N.H.,Wang, L.,Hasvold, L.,Wang, W.,Leonard, N.,Li, T.,Li, Q.,Cohen, J.,Gu, W.Z.,Zhang, H.,Stoll, V.,Bauch, J.,Marsh, K.,Rosenberg, S.H.,Sham, H.L. (deposition date: 2002-12-20, release date: 2004-04-06, Last modification date: 2011-07-13)
Primary citation
Tong, Y.,Lin, N.H.,Wang, L.,Hasvold, L.,Wang, W.,Leonard, N.,Li, T.,Li, Q.,Cohen, J.,Gu, W.Z.,Zhang, H.,Stoll, V.,Bauch, J.,Marsh, K.,Rosenberg, S.H.,Sham, H.L.
Discovery of potent imidazole and cyanophenyl containing farnesyltransferase inhibitors with improved oral bioavailability.
Bioorg.Med.Chem.Lett., 13:1571-1574, 2003
PubMed: 12699757 (PDB entries with the same primary citation)
DOI: 10.1016/S0960-894X(03)00195-1
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.3 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.313446.8%21.0%0.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution