1NI1

Imidazole and cyanophenyl farnesyl transferase inhibitors

1NI1 の概要

• エントリーDOI: 10.2210/pdb1ni1/pdb
• 関連するPDBエントリー: 1N95 1N9A
• 分子名称: Protein farnesyltransferase alpha subunit, Protein farnesyltransferase beta subunit, ZINC ION, ... (5 entities in total)
• 機能のキーワード: transferase, prenyltransferase, ftase, cyanophenyl
• 由来する生物種: Rattus norvegicus (Norway rat); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 83841.27

構造登録者

Tong, Y.,Lin, N.H.,Wang, L.,Hasvold, L.,Wang, W.,Leonard, N.,Li, T.,Li, Q.,Cohen, J.,Gu, W.Z.,Zhang, H.,Stoll, V.,Bauch, J.,Marsh, K.,Rosenberg, S.H.,Sham, H.L. (登録日: 2002-12-20, 公開日: 2004-04-06, 最終更新日: 2024-02-14)

主引用文献

Tong, Y.,Lin, N.H.,Wang, L.,Hasvold, L.,Wang, W.,Leonard, N.,Li, T.,Li, Q.,Cohen, J.,Gu, W.Z.,Zhang, H.,Stoll, V.,Bauch, J.,Marsh, K.,Rosenberg, S.H.,Sham, H.L.
Discovery of potent imidazole and cyanophenyl containing farnesyltransferase inhibitors with improved oral bioavailability.
Bioorg.Med.Chem.Lett., 13:1571-1574, 2003

PubMed Abstract: A pyridyl moiety was introduced into a previously developed series of farnesyltransferase inhibitors containing imidazole and cyanophenyl (such as 4), resulting in potent inhibitors with improved pharmacokinetics.

PubMed: 12699757
DOI: 10.1016/S0960-894X(03)00195-1

実験手法

X-RAY DIFFRACTION (2.3 Å)