1NHV

Hepatitis C virus RNA polymerase in complex with non-nucleoside analogue inhibitor

1NHV の概要

• エントリーDOI: 10.2210/pdb1nhv/pdb
• 分子名称: HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE, (2S)-2-[(5-BENZOFURAN-2-YL-THIOPHEN-2-YLMETHYL)-(2,4-DICHLORO-BENZOYL)-AMINO]-3-PHENYL-PROPIONIC ACID (2 entities in total)
• 機能のキーワード: hepatitis c; rna polymerase; enzyme inhibition, transferase
• 由来する生物種: Hepatitis C virus subtype 1b
• 細胞内の位置: Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein. Core protein p19: Virion . Envelope glycoprotein E1: Virion membrane ; Single-pass type I membrane protein . Envelope glycoprotein E2: Virion membrane ; Single-pass type I membrane protein . p7: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Protease NS2-3: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 5A: Host endoplasmic reticulum membrane ; Peripheral membrane protein . RNA-directed RNA polymerase: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein : P26663
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 129624.13

構造登録者

Wang, M.,Ng, K.K.S.,Cherney, M.M.,Chan, L.,Yannopoulos, C.G.,Bedard, J.,Morin, N.,Nguyen-Ba, N.,Alaoui-Ismaili, M.H.,Bethell, R.C.,James, M.N.G. (登録日: 2002-12-19, 公開日: 2003-03-18, 最終更新日: 2023-08-16)

• 主引用文献: Wang, M.,Ng, K.K.S.,Cherney, M.M.,Chan, L.,Yannopoulos, C.G.,Bedard, J.,Morin, N.,Nguyen-Ba, N.,Alaoui-Ismaili, M.H.,Bethell, R.C.,James, M.N.G.; Non-Nucleoside Analogue Inhibitors Bind to an Allosteric Site on HCV NS5B Polymerase: Crystal Structures and Mechanism of Inhibition; J.Biol.Chem., 278:9489-9495, 2003; PubMed: 12509436; DOI: 10.1074/jbc.M209397200

実験手法

X-RAY DIFFRACTION (2.9 Å)