1NF5

Crystal Structure of Lactose Synthase, Complex with Glucose

Replaces:  1J8W

Summary for 1NF5

DescriptorAlpha-lactalbumin, beta-1,4-galactosyltransferase, CALCIUM ION, ... (7 entities in total)
Functional Keywordslactose synhtase, glucose binding, conformational change, transferase modulator, transferase-transferase complex, transferase/transferase
Biological sourceMus musculus (house mouse)
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Cellular locationSecreted P29752
Isoform Long: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Isoform Short: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Processed beta-1,4-galactosyltransferase 1: Secreted P08037
Total number of polymer chains4
Total molecular weight94625.89
Authors
Ramakrishnan, B.,Qasba, P.K. (deposition date: 2002-12-13, release date: 2002-12-25, Last modification date: 2011-07-13)
Primary citation
Ramakrishnan, B.,Qasba, P.K.
Crystal Structure of Lactose Synthase Reveals a Large Conformational Change in its Catalytic Component, the beta-1,4-galactosyltransferase
J.Mol.Biol., 310:205-218, 2001
PubMed: 11419947 (PDB entries with the same primary citation)
DOI: 10.1006/jmbi.2001.4757
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.232130.1%5.5%3.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution