1NER

SOLUTION STRUCTURE OF THE MU NER PROTEIN BY MULTIDIMENSIONAL NMR

1NER の概要

• エントリーDOI: 10.2210/pdb1ner/pdb
• 分子名称: DNA-BINDING PROTEIN NER (1 entity in total)
• 機能のキーワード: dna-binding protein, dna binding protein
• 由来する生物種: Enterobacteria phage Mu
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 8388.54

構造登録者

Clore, G.M.,Strzelecka, T.E.,Gronenborn, A.M. (登録日: 1995-08-24, 公開日: 1995-12-07, 最終更新日: 2024-05-22)

主引用文献

Strzelecka, T.E.,Clore, G.M.,Gronenborn, A.M.
The solution structure of the Mu Ner protein reveals a helix-turn-helix DNA recognition motif.
Structure, 3:1087-1095, 1995

PubMed Abstract: The Mu Ner protein is a small (74 amino acids), basic, DNA-binding protein found in phage Mu. It belongs to a class of proteins, the cro and repressor proteins, that regulate the switch from the lysogenic to the lytic state of the phage life cycle. There is no significant sequence identity between Mu Ner and the cro proteins of other phages, despite their functional similarity. In addition, there is no significant sequence identity with any other DNA-binding proteins, with the exception of Ner from the related phage D108 and the Nlp protein of Escherichia coli. As the tertiary structures of Mu Ner and these two related proteins are unknown, it is clear that a three-dimensional (3D) structure of Mu Ner is essential in order to gain insight into its mode of DNA binding.

PubMed: 8590003
DOI: 10.1016/S0969-2126(01)00244-1

実験手法

SOLUTION NMR