1NCI

STRUCTURAL BASIS OF CELL-CELL ADHESION BY CADHERINS

Summary for 1NCI

• Entry DOI: 10.2210/pdb1nci/pdb
• Descriptor: N-CADHERIN, URANYL (VI) ION (3 entities in total)
• Functional Keywords: cadherin, cell adhesion protein
• Biological source: Mus musculus (house mouse)
• Cellular location: Cell membrane; Single-pass type I membrane protein: P15116
• Total number of polymer chains: 2
• Total formula weight: 24759.66

Authors

Shapiro, L.,Fannon, A.M.,Kwong, P.D.,Thompson, A.,Lehmann, M.S.,Grubel, G.,Legrand, J.-F.,Als-Nielsen, J.,Colman, D.R.,Hendrickson, W.A. (deposition date: 1995-03-23, release date: 1995-07-10, Last modification date: 2024-02-14)

Primary citation

Shapiro, L.,Fannon, A.M.,Kwong, P.D.,Thompson, A.,Lehmann, M.S.,Grubel, G.,Legrand, J.F.,Als-Nielsen, J.,Colman, D.R.,Hendrickson, W.A.
Structural basis of cell-cell adhesion by cadherins.
Nature, 374:327-337, 1995

PubMed Abstract: Crystal structures of the amino-terminal domain of N-cadherin provide a picture at the atomic level of a specific adhesive contact between cells. A repeated set of dimer interfaces is common to the structure in three lattices. These interactions combine to form a linear zipper of molecules that mirrors the linear structure of the intracellular filaments with which cadherins associate. This cell-adhesion zipper may provide a mechanism to marshal individual molecular adhesive interactions into strong bonds between cells.

PubMed: 7885471
DOI: 10.1038/374327a0

Experimental method

X-RAY DIFFRACTION (2.1 Å)