1NCG
STRUCTURAL BASIS OF CELL-CELL ADHESION BY CADHERINS
Summary for 1NCG
| Entry DOI | 10.2210/pdb1ncg/pdb |
| Descriptor | N-CADHERIN, YTTERBIUM (III) ION (3 entities in total) |
| Functional Keywords | cadherin, cell adhesion protein |
| Biological source | Mus musculus (house mouse) |
| Total number of polymer chains | 1 |
| Total formula weight | 12417.86 |
| Authors | Shapiro, L.,Fannon, A.M.,Kwong, P.D.,Thompson, A.,Lehmann, M.S.,Grubel, G.,Legrand, J.-F.,Als-Nielsen, J.,Colman, D.R.,Hendrickson, W.A. (deposition date: 1995-03-23, release date: 1995-07-10, Last modification date: 2024-02-14) |
| Primary citation | Shapiro, L.,Fannon, A.M.,Kwong, P.D.,Thompson, A.,Lehmann, M.S.,Grubel, G.,Legrand, J.F.,Als-Nielsen, J.,Colman, D.R.,Hendrickson, W.A. Structural basis of cell-cell adhesion by cadherins. Nature, 374:327-337, 1995 Cited by PubMed Abstract: Crystal structures of the amino-terminal domain of N-cadherin provide a picture at the atomic level of a specific adhesive contact between cells. A repeated set of dimer interfaces is common to the structure in three lattices. These interactions combine to form a linear zipper of molecules that mirrors the linear structure of the intracellular filaments with which cadherins associate. This cell-adhesion zipper may provide a mechanism to marshal individual molecular adhesive interactions into strong bonds between cells. PubMed: 7885471DOI: 10.1038/374327a0 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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