1NCG

STRUCTURAL BASIS OF CELL-CELL ADHESION BY CADHERINS

1NCG の概要

• エントリーDOI: 10.2210/pdb1ncg/pdb
• 分子名称: N-CADHERIN, YTTERBIUM (III) ION (3 entities in total)
• 機能のキーワード: cadherin, cell adhesion protein
• 由来する生物種: Mus musculus (house mouse)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 12417.86

構造登録者

Shapiro, L.,Fannon, A.M.,Kwong, P.D.,Thompson, A.,Lehmann, M.S.,Grubel, G.,Legrand, J.-F.,Als-Nielsen, J.,Colman, D.R.,Hendrickson, W.A. (登録日: 1995-03-23, 公開日: 1995-07-10, 最終更新日: 2024-02-14)

主引用文献

Shapiro, L.,Fannon, A.M.,Kwong, P.D.,Thompson, A.,Lehmann, M.S.,Grubel, G.,Legrand, J.F.,Als-Nielsen, J.,Colman, D.R.,Hendrickson, W.A.
Structural basis of cell-cell adhesion by cadherins.
Nature, 374:327-337, 1995

PubMed Abstract: Crystal structures of the amino-terminal domain of N-cadherin provide a picture at the atomic level of a specific adhesive contact between cells. A repeated set of dimer interfaces is common to the structure in three lattices. These interactions combine to form a linear zipper of molecules that mirrors the linear structure of the intracellular filaments with which cadherins associate. This cell-adhesion zipper may provide a mechanism to marshal individual molecular adhesive interactions into strong bonds between cells.

PubMed: 7885471
DOI: 10.1038/374327a0

実験手法

X-RAY DIFFRACTION (2.1 Å)