1NAB

The crystal structure of the complex between a disaccharide anthracycline and the DNA hexamer d(CGATCG) reveals two different binding sites involving two DNA duplexes

Summary for 1NAB

• Entry DOI: 10.2210/pdb1nab/pdb
• Descriptor: 5'-D(*CP*GP*AP*TP*CP*G)-3', 7-[5-(4-AMINO-5-HYDROXY-6-METHYL-TETRAHYDRO-PYRAN-2-YLOXY)-4-HYDROXY-6-METHYL-TETRAHYDRO-PYRAN-2-YLOXY]-6,9,11-TRIHYDROXY-9-(2-HYDROXY-ACETYL)-7,8,9,10-TETRAHYDRO-NAPHTHACENE-5,12-DIONE (3 entities in total)
• Functional Keywords: right handed dna, double helix, complexed with drug, dna
• Total number of polymer chains: 2
• Total formula weight: 4905.70

Authors

Temperini, C.,Messori, L.,Orioli, P.,Di Bugno, C.,Animati, F.,Ughetto, G. (deposition date: 2002-11-27, release date: 2003-02-25, Last modification date: 2024-02-14)

• Primary citation: Temperini, C.,Messori, L.,Orioli, P.,Di Bugno, C.,Animati, F.,Ughetto, G.; The crystal structure of the complex between a disaccharide anthracycline and the DNA hexamer d(CGATCG) reveals two different binding sites involving two DNA duplexes; Nucleic Acids Res., 31:1464-1469, 2003; PubMed: 12595554; DOI: 10.1093/nar/gkg245

Experimental method

X-RAY DIFFRACTION (2.15 Å)