1NAB

The crystal structure of the complex between a disaccharide anthracycline and the DNA hexamer d(CGATCG) reveals two different binding sites involving two DNA duplexes

1NAB の概要

• エントリーDOI: 10.2210/pdb1nab/pdb
• 分子名称: 5'-D(*CP*GP*AP*TP*CP*G)-3', 7-[5-(4-AMINO-5-HYDROXY-6-METHYL-TETRAHYDRO-PYRAN-2-YLOXY)-4-HYDROXY-6-METHYL-TETRAHYDRO-PYRAN-2-YLOXY]-6,9,11-TRIHYDROXY-9-(2-HYDROXY-ACETYL)-7,8,9,10-TETRAHYDRO-NAPHTHACENE-5,12-DIONE (3 entities in total)
• 機能のキーワード: right handed dna, double helix, complexed with drug, dna
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 4905.70

構造登録者

Temperini, C.,Messori, L.,Orioli, P.,Di Bugno, C.,Animati, F.,Ughetto, G. (登録日: 2002-11-27, 公開日: 2003-02-25, 最終更新日: 2024-02-14)

• 主引用文献: Temperini, C.,Messori, L.,Orioli, P.,Di Bugno, C.,Animati, F.,Ughetto, G.; The crystal structure of the complex between a disaccharide anthracycline and the DNA hexamer d(CGATCG) reveals two different binding sites involving two DNA duplexes; Nucleic Acids Res., 31:1464-1469, 2003; PubMed: 12595554; DOI: 10.1093/nar/gkg245

実験手法

X-RAY DIFFRACTION (2.15 Å)