1NA7

Crystal structure of the catalytic subunit of human protein kinase CK2

Summary for 1NA7

Entry DOI	10.2210/pdb1na7/pdb
Related	1A6O 1F0Q 1M2Q 1M2R
Descriptor	Casein kinase II, alpha chain (2 entities in total)
Functional Keywords	ck2, protein kinase, microcrystals, thin-film nanotechnology, microfocus esrf, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	39333.89
Authors	Pechkova, E.,Zanotti, G.,Nicolini, C. (deposition date: 2002-11-27, release date: 2003-08-26, Last modification date: 2023-08-16)
Primary citation	Pechkova, E.,Zanotti, G.,Nicolini, C. Three-dimensional atomic structure of a catalytic subunit mutant of human protein kinase CK2. Acta Crystallogr.,Sect.D, 59:2133-2139, 2003 Cited by PubMed Abstract: The three-dimensional crystal structure of the triple-point mutant of the catalytic subunit of human protein kinase CK2alpha has been determined at 2.4 A resolution. Microcrystals of mutant CK2 catalytic subunit were obtained by a protein-crystallization method based on thin-film nanotechnology. These microcrystals (of about 20 micro m in diameter) were used for diffraction data collection by means of the microfocus beamline at the ESRF synchrotron. A comparison between the human protein kinase CK2alpha and the corresponding enzyme from a lower organism (Zea mays) is made. PubMed: 14646071 DOI: 10.1107/S0907444903018900 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation