1N7I

The structure of Phenylethanolamine N-methyltransferase in complex with S-adenosylhomocysteine and the inhibitor LY134046

1N7I の概要

• エントリーDOI: 10.2210/pdb1n7i/pdb
• 関連するPDBエントリー: 1HNN
• 分子名称: Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, 8,9-DICHLORO-2,3,4,5-TETRAHYDRO-1H-BENZO[C]AZEPINE, ... (4 entities in total)
• 機能のキーワード: methyltransferase, catecholamine, adrenaline, epinephrine, s-adenosylmethionine, s-adenolsylhomocysteine, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 62977.00

構造登録者

McMillan, F.M.,Archbold, J.,McLeish, M.J.,Caine, J.M.,Criscione, K.R.,Grunewald, G.L.,Martin, J.L. (登録日: 2002-11-15, 公開日: 2003-12-23, 最終更新日: 2024-02-14)

• 主引用文献: McMillan, F.M.,Archbold, J.,McLeish, M.J.,Caine, J.M.,Criscione, K.R.,Grunewald, G.L.,Martin, J.L.; Molecular recognition of sub-micromolar inhibitors by the epinephrine-synthesizing enzyme phenylethanolamine N-methyltransferase.; J.Med.Chem., 47:37-44, 2004; PubMed: 14695818; DOI: 10.1021/jm0205752

実験手法

X-RAY DIFFRACTION (2.8 Å)