1N1F

Crystal Structure of Human Interleukin-19

1N1F の概要

• エントリーDOI: 10.2210/pdb1n1f/pdb
• 分子名称: interleukin-19, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
• 機能のキーワード: cytokine, interleukin, four helix bundle, immune system
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 18610.30

構造登録者

Chang, C.,Magracheva, E.,Kozlov, S.,Fong, S.,Tobin, G.,Kotenko, S.,Wlodawer, A.,Zdanov, A. (登録日: 2002-10-17, 公開日: 2003-02-04, 最終更新日: 2024-10-30)

主引用文献

Chang, C.,Magracheva, E.,Kozlov, S.,Fong, S.,Tobin, G.,Kotenko, S.,Wlodawer, A.,Zdanov, A.
Crystal structure of interleukin-19 defines a new subfamily of helical cytokines
J.Biol.Chem., 278:3308-3313, 2003

PubMed Abstract: Interleukin-19 (IL-19) is a novel cytokine that was initially identified during a sequence data base search aimed at finding potential IL-10 homologs. IL-19 shares a receptor complex with IL-20, indicating that the biological activities of these two cytokines overlap and that both may play an important role in regulating development and proper functioning of the skin. We determined the crystal structure of human recombinant IL-19 and refined it at 1.95-A resolution to an R-factor of 0.157. Unlike IL-10, which forms an intercalated dimer, the molecule of IL-19 is a monomer made of seven amphipathic helices, A-G, creating a unique helical bundle. On the basis of the observed structure, we propose that IL-19, IL-20, and other putative members of the proposed IL-10 family together form a distinct subfamily of helical cytokines.

PubMed: 12403790
DOI: 10.1074/jbc.M208602200

実験手法

X-RAY DIFFRACTION (1.95 Å)