1MYN

SOLUTION STRUCTURE OF DROSOMYCIN, THE FIRST INDUCIBLE ANTIFUNGAL PROTEIN FROM INSECTS, NMR, 15 STRUCTURES

Summary for 1MYN

• Entry DOI: 10.2210/pdb1myn/pdb
• Descriptor: DROSOMYCIN (1 entity in total)
• Functional Keywords: drosomycin, insect immunity, antifungal, csalpha-beta motif, signal protein
• Biological source: Drosophila melanogaster (fruit fly)
• Cellular location: Secreted: P41964
• Total number of polymer chains: 1
• Total formula weight: 4905.58

Authors

Landon, C.,Sodano, P.,Hetru, C.,Hoffmann, J.A.,Ptak, M. (deposition date: 1996-12-26, release date: 1997-12-31, Last modification date: 2024-11-20)

Primary citation

Landon, C.,Sodano, P.,Hetru, C.,Hoffmann, J.,Ptak, M.
Solution structure of drosomycin, the first inducible antifungal protein from insects.
Protein Sci., 6:1878-1884, 1997

PubMed Abstract: Drosomycin is the first antifungal protein characterized recently among the broad family of inducible peptides and proteins produced by insects to respond to bacterial or septic injuries. It is a small protein of 44 amino acid residues extracted from Drosophila melanogaster that exhibits a potent activity against filamentous fungi. Its three-dimensional structure in aqueous solution was determined using 1H 2D NMR. This structure, involving an alpha-helix and a twisted three-stranded beta-sheet, is stabilized by three disulfide bridges. The corresponding Cysteine Stabilized alpha beta (CS alpha beta) motif, which was found in other defense proteins such as the antibacterial insect defensin A, short- and long-chain scorpion toxins, as well as in plant thionins and potent antifungal plant defensins, appears as remarkably persistent along evolution.

PubMed: 9300487

Experimental method

SOLUTION NMR