1MVG

NMR solution structure of chicken Liver basic Fatty Acid Binding Protein (Lb-FABP)

1MVG の概要

• エントリーDOI: 10.2210/pdb1mvg/pdb
• 分子名称: Liver basic Fatty Acid Binding Protein (1 entity in total)
• 機能のキーワード: beta-barrel, calycin, ten antiparallel beta strands, helix-turn-helix motif, fatty acid binding protein, transport protein
• 由来する生物種: Gallus gallus (chicken)
• 細胞内の位置: Cytoplasm: P80226
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 14100.18

構造登録者

Vasile, F.,Ragona, L.,Catalano, M.,Zetta, L.,Perduca, M.,Monaco, H.,Molinari, H. (登録日: 2002-09-25, 公開日: 2003-03-04, 最終更新日: 2024-05-22)

主引用文献

Vasile, F.,Ragona, L.,Catalano, M.,Zetta, L.,Perduca, M.,Monaco, H.,Molinari, H.
Solution Structure of chicken Liver basic type Fatty Acid Binding Protein
J.BIOMOL.NMR, 25:157-160, 2003

PubMed Abstract: Chicken liver basic fatty acid binding protein (Lb-FABP) belongs to the basic-type fatty acid binding proteins, a novel group of proteins isolated from liver of different non mammalian species whose structure is not known. The structure of Lb-FABP has been solved by (1)H NMR. The overall fold of Lb-FABP, common to the other proteins of the family, consists of ten antiparallel beta-strands organised in two nearly ortogonal beta-sheets with two alpha helices closing the protein cavity where small hydrophobic ligands can be bound. The binding specificity of the protein is not known, however, based on the high sequence and structural similarity with an orthologous protein, ileal lipid binding protein, it is suggested that bile acids may be the putative ligands.

PubMed: 12652125
DOI: 10.1023/A:1022277727303

実験手法

SOLUTION NMR