1MS6

Dipeptide Nitrile Inhibitor Bound to Cathepsin S.

1MS6 の概要

• エントリーDOI: 10.2210/pdb1ms6/pdb
• 分子名称: Cathepsin S, MORPHOLINE-4-CARBOXYLIC ACID [1S-(2-BENZYLOXY-1R-CYANO-ETHYLCARBAMOYL)-3-METHYL-BUTYL]AMIDE (2 entities in total)
• 機能のキーワード: hydrolase, cathepsin, protease
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Lysosome: P25774
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 25100.16

構造登録者

Ward, Y.D.,Thomson, D.S.,Frye, L.L.,Cywin, C.L.,Morwick, T.,Emmanuel, M.J.,Zindell, R.,McNeil, D.,Bekkali, Y.,Giradot, M.,Hrapchak, M.,DeTuri, M.,Crane, K.,White, D.,Pav, S.,Wang, Y.,Hao, M.H.,Grygon, C.A.,Labadia, M.E.,Freeman, D.M.,Davidson, W.,Hopkins, J.L.,Brown, M.L.,Spero, D.M. (登録日: 2002-09-19, 公開日: 2003-04-22, 最終更新日: 2011-07-13)

• 主引用文献: Ward, Y.D.,Thomson, D.S.,Frye, L.L.,Cywin, C.L.,Morwick, T.,Emmanuel, M.J.,Zindell, R.,McNeil, D.,Bekkali, Y.,Giradot, M.,Hrapchak, M.,DeTuri, M.,Crane, K.,White, D.,Pav, S.,Wang, Y.,Hao, M.H.,Grygon, C.A.,Labadia, M.E.,Freeman, D.M.,Davidson, W.,Hopkins, J.L.,Brown, M.L.,Spero, D.M.; Design and synthesis of dipeptide nitriles as reversible and potent Cathepsin S inhibitors; J.Med.Chem., 45:5471-5482, 2002; PubMed: 12459015; DOI: 10.1021/jm020209i

実験手法

X-RAY DIFFRACTION (1.9 Å)