1MP7

A Third Complex of Post-Activated Neocarzinostatin Chromophore with DNA. Bulge DNA Binding from the Minor Groove

1MP7 の概要

• エントリーDOI: 10.2210/pdb1mp7/pdb
• 関連するPDBエントリー: 1KVH
• 分子名称: 5'-D(*GP*CP*CP*AP*GP*AP*GP*AP*GP*C)-3', [(R)-4-((1,3-DIOXOLANE-2-OXY)-4-(S)-YL)-4-HYDROXY]-(R)-10-(2-METHYLAMINO-5-METHYL-2,6-DIDEOXYGALACTOPYRANOSYL-OXY)-(R)-11-(2-HYDROXY-5-METHYL-7-METHOXY-1-NAPHTHOYL-OXY)-(R)-12-S-GLUTATHIONYL-4,10,11,12-TETRAHYDROINDACENE (2 entities in total)
• 機能のキーワード: dna-drug complex, bulge dna, recognition of anticancer, dna
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 4048.01

構造登録者

Kwon, Y.,Xi, Z.,Kappen, L.S.,Goldberg, I.H.,Gao, X. (登録日: 2002-09-11, 公開日: 2003-02-18, 最終更新日: 2024-05-22)

• 主引用文献: Kwon, Y.,Xi, Z.,Kappen, L.S.,Goldberg, I.H.,Gao, X.; New Complex of Post-Activated Neocarzinostatin Chromophore with DNA: Bulge DNA Binding from the Minor Groove; Biochemistry, 42:1186-1198, 2003; PubMed: 12564921; DOI: 10.1021/bi0206210

実験手法

SOLUTION NMR