1MOU

Crystal structure of Coral pigment

1MOU の概要

• エントリーDOI: 10.2210/pdb1mou/pdb
• 関連するPDBエントリー: 1MOV
• 分子名称: GFP-like non-fluorescent chromoprotein, IODIDE ION (3 entities in total)
• 機能のキーワード: blue coral pigment, chromophore, beta can fold, similar to green fluorescent protein and dsred, luminescent protein
• 由来する生物種: Montipora efflorescens
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 25449.64

構造登録者

Prescott, M.,Ling, M.,Beddoe, T.,Oakley, A.J.,Dove, S.,Hoegh-Guldberg, O.,Devenish, R.J.,Rossjohn, J. (登録日: 2002-09-10, 公開日: 2003-04-08, 最終更新日: 2024-10-23)

主引用文献

Prescott, M.,Ling, M.,Beddoe, T.,Oakley, A.J.,Dove, S.,Hoegh-Guldberg, O.,Devenish, R.J.,Rossjohn, J.
The 2.2 a crystal structure of a pocilloporin pigment reveals a nonplanar chromophore conformation.
Structure, 11:275-284, 2003

PubMed Abstract: Reef-building corals contain host pigments, termed pocilloporins, that function to regulate the light environment of their resident microalgae by acting as a photoprotectant in excessive sunlight. We have determined the crystal structure of an intensely blue, nonfluorescent pocilloporin to 2.2 A resolution and a genetically engineered fluorescent variant to 2.4 A resolution. The pocilloporin chromophore structure adopts a markedly different conformation in comparison with the DsRed chromophore, despite the chromophore sequences (Gln-Tyr-Gly) being identical; the tyrosine ring of the pocilloporin chromophore is noncoplanar and in the trans configuration. Furthermore, the fluorescent variant adopted a noncoplanar chromophore conformation. The data presented here demonstrates that the conformation of the chromophore is highly dependent on its immediate environment.

PubMed: 12623015
DOI: 10.1016/S0969-2126(03)00028-5

実験手法

X-RAY DIFFRACTION (2.2 Å)