1MOF

COAT PROTEIN

1MOF の概要

• エントリーDOI: 10.2210/pdb1mof/pdb
• 分子名称: MOLONEY MURINE LEUKEMIA VIRUS P15, CHLORIDE ION (3 entities in total)
• 機能のキーワード: glycoprotein, coat protein, polyprotein, transmembrane, sign, viral protein
• 由来する生物種: Moloney murine leukemia virus
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 6204.50

構造登録者

Fass, D.,Harrison, S.C.,Kim, P.S. (登録日: 1996-04-02, 公開日: 1996-10-14, 最終更新日: 2024-10-30)

主引用文献

Fass, D.,Harrison, S.C.,Kim, P.S.
Retrovirus envelope domain at 1.7 angstrom resolution.
Nat.Struct.Biol., 3:465-469, 1996

PubMed Abstract: We report the crystal structure of an extraviral segment of a retrovirus envelope protein, the Moloney murine leukemia virus (MoMuLV) transmembrane (TM) subunit. This segment, which comprises a region of the MoMuLV TM protein analogous to that contained within the X-ray crystal structure of low-pH converted influenza hemagglutinin, contains a trimeric coiled coil, with a hydrophobic cluster at its base and a strand that packs in an antiparallel orientation against the coiled coil. This structure gives the first high-resolution insight into the retrovirus surface and serves as a model for a wide range of viral fusion proteins; key residues in this structure are conserved among C- and D-type retroviruses and the filovirus ebola.

PubMed: 8612078
DOI: 10.1038/nsb0596-465

実験手法

X-RAY DIFFRACTION (1.7 Å)