1MNC

STRUCTURE OF HUMAN NEUTROPHIL COLLAGENASE REVEALS LARGE S1' SPECIFICITY POCKET

1MNC の概要

• エントリーDOI: 10.2210/pdb1mnc/pdb
• 分子名称: NEUTROPHIL COLLAGENASE, ZINC ION, CALCIUM ION, ... (5 entities in total)
• 機能のキーワード: hydrolase (metalloprotease)
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 18399.78

構造登録者

Stams, T.,Spurlino, J.C.,Smith, D.L.,Rubin, B. (登録日: 1994-01-12, 公開日: 1995-02-07, 最終更新日: 2024-02-14)

主引用文献

Stams, T.,Spurlino, J.C.,Smith, D.L.,Wahl, R.C.,Ho, T.F.,Qoronfleh, M.W.,Banks, T.M.,Rubin, B.
Structure of human neutrophil collagenase reveals large S1' specificity pocket.
Nat.Struct.Biol., 1:119-123, 1994

PubMed Abstract: The crystal structure of the catalytic domain of human neutrophil collagenase complexed with a peptide transition state analogue has been determined to a resolution of 2.1 A. The structure of the neutrophil enzyme, when compared with the three dimensional structure of the corresponding human fibroblast collagenase, shows differences in the first, S1', of the three enzyme specificity subsites on the carboxy-terminal side of the substrate scissile bond. The S1' pocket in the neutrophil collagenase is significantly larger than the equivalent site in the fibroblast enzyme, suggesting that the former enzyme has a broader range of possible substrates. Such differences also suggest approaches for the design of selective matrix metalloproteinase inhibitors.

PubMed: 7656015
DOI: 10.1038/nsb0294-119

実験手法

X-RAY DIFFRACTION (2.1 Å)