1MLX

Crystal Structure Analysis of a 2'-O-[2-(Methylthio)-ethyl]-Modified Oligodeoxynucleotide Duplex

Summary for 1MLX

Descriptor5'-D(*GP*CP*GP*TP*AP*SMTP*AP*CP*GP*C)-3' (2 entities in total)
Functional Keywordsdna, double helix, a-form, antisense modification, nucleic acid analogue, rna affinity, nuclease resistance, protein binding affinity, high resolution structure, hydration
Total number of polymer chains2
Total molecular weight6270.3
Authors
Prakash, T.P.,Manoharan, M.,Kawasaki, A.M.,Fraser, A.S.,Lesnik, E.A.,Sioufi, N.,Leeds, J.M.,Teplova, M.,Egli, M. (deposition date: 2002-08-31, release date: 2002-12-04, Last modification date: 2017-10-11)
Primary citation
Prakash, T.P.,Manoharan, M.,Kawasaki, A.M.,Fraser, A.S.,Lesnik, E.A.,Sioufi, N.,Leeds, J.M.,Teplova, M.,Egli, M.
2'-O-[2-(Methylthio)ethyl]-Modified Oligonucleotide: An Analogue of 2'-O-[2-(Methoxy)-ethyl]-Modified Oligonucleotide with Improved Protein Binding Properties and High Binding Affinity to Target RNA
Biochemistry, 41:11642-11648, 2002
PubMed: 12269806 (PDB entries with the same primary citation)
DOI: 10.1021/bi020264t
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.25 Å)
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Structure validation

RfreeClashscoreRSRZ outliers0.15820MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution