1MKX
THE CO-CRYSTAL STRUCTURE OF UNLIGANDED BOVINE ALPHA-THROMBIN AND PRETHROMBIN-2: MOVEMENT OF THE YPPW SEGMENT AND ACTIVE SITE RESIDUES UPON LIGAND BINDING
Summary for 1MKX
Entry DOI | 10.2210/pdb1mkx/pdb |
Descriptor | ALPHA-THROMBIN, PRETHROMBIN-2, ... (4 entities in total) |
Functional Keywords | complex (blood coagulation-proenzyme), thrombin, prethrombin-2, plasma, serine protease, complex (blood coagulation-proenzyme) complex, complex (blood coagulation/proenzyme) |
Biological source | Bos taurus (cattle) More |
Cellular location | Secreted, extracellular space: P00735 P00735 P00735 |
Total number of polymer chains | 3 |
Total formula weight | 70997.29 |
Authors | Malkowski, M.G.,Edwards, B.F.P. (deposition date: 1997-03-13, release date: 1997-07-07, Last modification date: 2024-06-05) |
Primary citation | Malkowski, M.G.,Martin, P.D.,Guzik, J.C.,Edwards, B.F. The co-crystal structure of unliganded bovine alpha-thrombin and prethrombin-2: movement of the Tyr-Pro-Pro-Trp segment and active site residues upon ligand binding. Protein Sci., 6:1438-1448, 1997 Cited by PubMed: 9232645PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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