1MKW

THE CO-CRYSTAL STRUCTURE OF UNLIGANDED BOVINE ALPHA-THROMBIN AND PRETHROMBIN-2: MOVEMENT OF THE YPPW SEGMENT AND ACTIVE SITE RESIDUES UPON LIGAND BINDING

Summary for 1MKW

Entry DOI	10.2210/pdb1mkw/pdb
Descriptor	ALPHA-THROMBIN, PRETHROMBIN-2, ... (4 entities in total)
Functional Keywords	complex (blood coagulation-proenzyme), thrombin, prethrombin-2, plasma, serine protease, complex (blood coagulation-proenzyme) complex, complex (blood coagulation/proenzyme)
Biological source	Bos taurus (cattle) More
Cellular location	Secreted, extracellular space: P00735 P00735 P00735
Total number of polymer chains	3
Total formula weight	70997.29
Authors	Malkowski, M.G.,Edwards, B.F.P. (deposition date: 1997-03-13, release date: 1997-07-07, Last modification date: 2011-07-13)
Primary citation	Malkowski, M.G.,Martin, P.D.,Guzik, J.C.,Edwards, B.F. The co-crystal structure of unliganded bovine alpha-thrombin and prethrombin-2: movement of the Tyr-Pro-Pro-Trp segment and active site residues upon ligand binding. Protein Sci., 6:1438-1448, 1997 Cited by PubMed: 9232645 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation