1MIR

RAT PROCATHEPSIN B

1MIR の概要

• エントリーDOI: 10.2210/pdb1mir/pdb
• 分子名称: PROCATHEPSIN B (2 entities in total)
• 機能のキーワード: hydrolase, thiol protease, cysteine protease
• 由来する生物種: Rattus norvegicus (Norway rat)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 71267.25

構造登録者

Cygler, M.,Sivaraman, J.,Grochulski, P.,Coulombe, R.,Storer, A.C.,Mort, J.S. (登録日: 1996-01-12, 公開日: 1997-01-11, 最終更新日: 2024-10-30)

主引用文献

Cygler, M.,Sivaraman, J.,Grochulski, P.,Coulombe, R.,Storer, A.C.,Mort, J.S.
Structure of rat procathepsin B: model for inhibition of cysteine protease activity by the proregion.
Structure, 4:405-416, 1996

PubMed Abstract: Cysteine proteases of the papain superfamily are synthesized as inactive precursors with a 60-110 residue N-terminal prosegment. The propeptides are potent inhibitors of their parent proteases. Although the proregion binding mode has been elucidated for all other protease classes, that of the cysteine proteases remained elusive.

PubMed: 8740363
DOI: 10.1016/S0969-2126(96)00046-9

実験手法

X-RAY DIFFRACTION (2.8 Å)