1MHO

THE 2.0 A STRUCTURE OF HOLO S100B FROM BOVINE BRAIN

1MHO の概要

• エントリーDOI: 10.2210/pdb1mho/pdb
• 分子名称: S-100 PROTEIN, CALCIUM ION (3 entities in total)
• 機能のキーワード: calcium-binding, metal-binding
• 由来する生物種: Bos taurus (cattle)
• 細胞内の位置: Cytoplasm: P02638
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 10234.56

構造登録者

Matsumura, H.,Shiba, T.,Inoue, T.,Harada, S.,Yasushi, K.A.I. (登録日: 1997-09-11, 公開日: 1998-11-18, 最終更新日: 2024-04-03)

主引用文献

Matsumura, H.,Shiba, T.,Inoue, T.,Harada, S.,Kai, Y.
A novel mode of target recognition suggested by the 2.0 A structure of holo S100B from bovine brain.
Structure, 6:233-241, 1998

PubMed Abstract: S100B, a small acidic calcium-binding protein, is a member of the S100 protein family and is a multifunctional protein capable of binding several target molecules, such as cytoskeletal proteins and protein kinases, in a calcium-dependent manner. S100B is a homodimer of S100 beta subunits (beta beta) with a total of four calcium-binding motifs called EF hands. S100B is found abundantly in nervous tissue and has been implicated in Alzheimer's disease and Down's syndrome. Structural analysis of S100B in the calcium-bound state is required to gain a better understanding of the conformational changes that occur to S100B upon calcium binding and to elucidate the mode of recognition between S100B and its target molecules.

PubMed: 9519413
DOI: 10.1016/S0969-2126(98)00024-0

実験手法

X-RAY DIFFRACTION (2 Å)