1MF4
Structure-based design of potent and selective inhibitors of phospholipase A2: Crystal structure of the complex formed between phosholipase A2 from Naja Naja sagittifera and a designed peptide inhibitor at 1.9 A resolution
Summary for 1MF4
Entry DOI | 10.2210/pdb1mf4/pdb |
Related | 1LFF 1LN8 |
Descriptor | Phospholipase A2, VAL-ALA-PHE-ARG-SER, CALCIUM ION, ... (4 entities in total) |
Functional Keywords | naja naja sagittifera, phospholipase a2, designed inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Naja sagittifera More |
Cellular location | Secreted: P60045 |
Total number of polymer chains | 2 |
Total formula weight | 13748.26 |
Authors | Singh, R.K.,Vikram, P.,Paramsivam, M.,Jabeen, T.,Sharma, S.,Makker, J.,Dey, S.,Kaur, P.,Srinivasan, A.,Singh, T.P. (deposition date: 2002-08-09, release date: 2003-09-30, Last modification date: 2011-07-13) |
Primary citation | Singh, R.K.,Vikram, P.,Makker, J.,Jabeen, T.,Sharma, S.,Dey, S.,Kaur, P.,Srinivasan, A.,Singh, T.P. Design of specific peptide inhibitors for group I phospholipase A2: structure of a complex formed between phospholipase A2 from Naja naja sagittifera (group I) and a designed peptide inhibitor Val-Ala-Phe-Arg-Ser (VAFRS) at 1.9 A resolution reveals unique features Biochemistry, 42:11701-11706, 2003 Cited by PubMed: 14529280DOI: 10.1021/bi035076x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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