1MF4
Structure-based design of potent and selective inhibitors of phospholipase A2: Crystal structure of the complex formed between phosholipase A2 from Naja Naja sagittifera and a designed peptide inhibitor at 1.9 A resolution
1MF4 の概要
エントリーDOI | 10.2210/pdb1mf4/pdb |
関連するPDBエントリー | 1LFF 1LN8 |
分子名称 | Phospholipase A2, VAL-ALA-PHE-ARG-SER, CALCIUM ION, ... (4 entities in total) |
機能のキーワード | naja naja sagittifera, phospholipase a2, designed inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
由来する生物種 | Naja sagittifera 詳細 |
細胞内の位置 | Secreted: P60045 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 13748.26 |
構造登録者 | Singh, R.K.,Vikram, P.,Paramsivam, M.,Jabeen, T.,Sharma, S.,Makker, J.,Dey, S.,Kaur, P.,Srinivasan, A.,Singh, T.P. (登録日: 2002-08-09, 公開日: 2003-09-30, 最終更新日: 2011-07-13) |
主引用文献 | Singh, R.K.,Vikram, P.,Makker, J.,Jabeen, T.,Sharma, S.,Dey, S.,Kaur, P.,Srinivasan, A.,Singh, T.P. Design of specific peptide inhibitors for group I phospholipase A2: structure of a complex formed between phospholipase A2 from Naja naja sagittifera (group I) and a designed peptide inhibitor Val-Ala-Phe-Arg-Ser (VAFRS) at 1.9 A resolution reveals unique features Biochemistry, 42:11701-11706, 2003 Cited by PubMed: 14529280DOI: 10.1021/bi035076x 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.9 Å) |
構造検証レポート
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