1MET
HIV-1 MUTANT (V82F) PROTEASE COMPLEXED WITH DMP323
Summary for 1MET
Entry DOI | 10.2210/pdb1met/pdb |
Descriptor | HIV-1 PROTEASE, [4-R-(-4-ALPHA,5-ALPHA,6-BETA,7-BETA)]-HEXAHYDRO-5,6-BIS(HYDROXY)-[1,3-BIS([4-HYDROXYMETHYL-PHENYL]METHYL)-4,7-BIS(PHEN YLMETHYL)]-2H-1,3-DIAZEPINONE (2 entities in total) |
Functional Keywords | hydrolase, acid proteinase, aspartyl protease |
Biological source | Human immunodeficiency virus 1 |
Cellular location | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366 |
Total number of polymer chains | 2 |
Total formula weight | 22242.23 |
Authors | Ala, P.,Chang, C.-H. (deposition date: 1997-04-11, release date: 1998-04-15, Last modification date: 2024-05-22) |
Primary citation | Ala, P.J.,Huston, E.E.,Klabe, R.M.,McCabe, D.D.,Duke, J.L.,Rizzo, C.J.,Korant, B.D.,DeLoskey, R.J.,Lam, P.Y.,Hodge, C.N.,Chang, C.H. Molecular basis of HIV-1 protease drug resistance: structural analysis of mutant proteases complexed with cyclic urea inhibitors. Biochemistry, 36:1573-1580, 1997 Cited by PubMed: 9048541DOI: 10.1021/bi962234u PDB entries with the same primary citation |
Experimental method |
Structure validation
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