1MET
HIV-1 MUTANT (V82F) PROTEASE COMPLEXED WITH DMP323
1MET の概要
エントリーDOI | 10.2210/pdb1met/pdb |
分子名称 | HIV-1 PROTEASE, [4-R-(-4-ALPHA,5-ALPHA,6-BETA,7-BETA)]-HEXAHYDRO-5,6-BIS(HYDROXY)-[1,3-BIS([4-HYDROXYMETHYL-PHENYL]METHYL)-4,7-BIS(PHEN YLMETHYL)]-2H-1,3-DIAZEPINONE (2 entities in total) |
機能のキーワード | hydrolase, acid proteinase, aspartyl protease |
由来する生物種 | Human immunodeficiency virus 1 |
細胞内の位置 | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 22242.23 |
構造登録者 | |
主引用文献 | Ala, P.J.,Huston, E.E.,Klabe, R.M.,McCabe, D.D.,Duke, J.L.,Rizzo, C.J.,Korant, B.D.,DeLoskey, R.J.,Lam, P.Y.,Hodge, C.N.,Chang, C.H. Molecular basis of HIV-1 protease drug resistance: structural analysis of mutant proteases complexed with cyclic urea inhibitors. Biochemistry, 36:1573-1580, 1997 Cited by PubMed: 9048541DOI: 10.1021/bi962234u 主引用文献が同じPDBエントリー |
実験手法 |
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