1MER

HIV-1 MUTANT (I84V) PROTEASE COMPLEXED WITH DMP450

1MER の概要

• エントリーDOI: 10.2210/pdb1mer/pdb
• 分子名称: HIV-1 PROTEASE, [4-R-(-4-ALPHA,5-ALPHA,6-BETA,7-BETA)]-HEXAHYDRO-5,6-BIS(HYDROXY)-1,3-BIS([(3-AMINO)PHENYL]METHYL)-4,7-BIS(PHENYLMETHYL)-2H-1,3-DIAZEPINONE (2 entities in total)
• 機能のキーワード: hydrolase, acid proteinase, aspartyl protease
• 由来する生物種: Human immunodeficiency virus 1
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22088.07

構造登録者

Ala, P.,Chang, C.-H. (登録日: 1997-04-11, 公開日: 1998-04-15, 最終更新日: 2024-05-22)

• 主引用文献: Ala, P.J.,Huston, E.E.,Klabe, R.M.,McCabe, D.D.,Duke, J.L.,Rizzo, C.J.,Korant, B.D.,DeLoskey, R.J.,Lam, P.Y.,Hodge, C.N.,Chang, C.H.; Molecular basis of HIV-1 protease drug resistance: structural analysis of mutant proteases complexed with cyclic urea inhibitors.; Biochemistry, 36:1573-1580, 1997; PubMed: 9048541; DOI: 10.1021/bi962234u

実験手法

X-RAY DIFFRACTION (1.9 Å)