1MCP

PHOSPHOCHOLINE BINDING IMMUNOGLOBULIN FAB MC/PC603. AN X-RAY DIFFRACTION STUDY AT 2.7 ANGSTROMS

Summary for 1MCP

• Entry DOI: 10.2210/pdb1mcp/pdb
• Descriptor: IGA-KAPPA MCPC603 FAB (LIGHT CHAIN), IGA-KAPPA MCPC603 FAB (HEAVY CHAIN), SULFATE ION, ... (4 entities in total)
• Functional Keywords: immunoglobulin
• Biological source: Mus musculus (house mouse); More
• Total number of polymer chains: 2
• Total formula weight: 48528.91

Authors

Satow, Y.,Cohen, G.H.,Padlan, E.A.,Davies, D.R. (deposition date: 1984-07-09, release date: 1985-01-02, Last modification date: 2024-11-13)

Primary citation

Satow, Y.,Cohen, G.H.,Padlan, E.A.,Davies, D.R.
Phosphocholine binding immunoglobulin Fab McPC603. An X-ray diffraction study at 2.7 A.
J.Mol.Biol., 190:593-604, 1986

PubMed Abstract: The crystal structure of the Fab of McPC603, a phosphocholine-binding mouse myeloma protein, has been refined at 2.7 A resolution by a combination of restrained least-squares refinement and molecular modeling. The overall structure remains as previously reported, with an elbow bend angle between the variable and constant modules of 133 degrees. Some adjustments have been made in the structure of the loops as a result of the refinement. The hypervariable loops are all visible in the electron density map with the exception of three residues in the first hypervariable loop of the light chain. A sulfate ion occupies the site of binding of the phosphate moiety of phosphocholine.

PubMed: 3097327
DOI: 10.1016/0022-2836(86)90245-7

Experimental method

X-RAY DIFFRACTION (2.7 Å)