1MCP

PHOSPHOCHOLINE BINDING IMMUNOGLOBULIN FAB MC/PC603. AN X-RAY DIFFRACTION STUDY AT 2.7 ANGSTROMS

1MCP の概要

• エントリーDOI: 10.2210/pdb1mcp/pdb
• 分子名称: IGA-KAPPA MCPC603 FAB (LIGHT CHAIN), IGA-KAPPA MCPC603 FAB (HEAVY CHAIN), SULFATE ION, ... (4 entities in total)
• 機能のキーワード: immunoglobulin
• 由来する生物種: Mus musculus (house mouse); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 48528.91

構造登録者

Satow, Y.,Cohen, G.H.,Padlan, E.A.,Davies, D.R. (登録日: 1984-07-09, 公開日: 1985-01-02, 最終更新日: 2024-11-13)

主引用文献

Satow, Y.,Cohen, G.H.,Padlan, E.A.,Davies, D.R.
Phosphocholine binding immunoglobulin Fab McPC603. An X-ray diffraction study at 2.7 A.
J.Mol.Biol., 190:593-604, 1986

PubMed Abstract: The crystal structure of the Fab of McPC603, a phosphocholine-binding mouse myeloma protein, has been refined at 2.7 A resolution by a combination of restrained least-squares refinement and molecular modeling. The overall structure remains as previously reported, with an elbow bend angle between the variable and constant modules of 133 degrees. Some adjustments have been made in the structure of the loops as a result of the refinement. The hypervariable loops are all visible in the electron density map with the exception of three residues in the first hypervariable loop of the light chain. A sulfate ion occupies the site of binding of the phosphate moiety of phosphocholine.

PubMed: 3097327
DOI: 10.1016/0022-2836(86)90245-7

実験手法

X-RAY DIFFRACTION (2.7 Å)