Regulatory Segment of Mouse 3',5'-Cyclic Nucleotide Phosphodiesterase 2A, Containing the GAF A and GAF B Domains

Summary for 1MC0

Descriptor3',5'-cyclic nucleotide phosphodiesterase 2A, CYCLIC GUANOSINE MONOPHOSPHATE (3 entities in total)
Functional Keywordsgaf domain, 3', 5'-cyclic nucleotide phosphodiesterase, 5'-guanosine monophosphate, hydrolase
Biological sourceMus musculus (house mouse)
Cellular locationMembrane; Peripheral membrane protein (Potential) Q922S4
Total number of polymer chains1
Total molecular weight41769.12
Martinez, S.,Wu, A.,Glavas, N.,Tang, X.,Turley, S.,Hol, W.,Beavo, J. (deposition date: 2002-08-04, release date: 2002-10-02, Last modification date: 2011-07-13)
Primary citation
Martinez, S.E.,Wu, A.Y.,Glavas, N.A.,Tang, X.B.,Turley, S.,Hol, W.G.,Beavo, J.A.
The two GAF domains in phosphodiesterase 2A have distinct roles in dimerization and in cGMP binding.
Proc.Natl.Acad.Sci.USA, 99:13260-13265, 2002
PubMed: 12271124 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.192374899
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.262242.9%6.4%5.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution