1MAB

RAT LIVER F1-ATPASE

1MAB の概要

• エントリーDOI: 10.2210/pdb1mab/pdb
• 分子名称: PROTEIN (F1-ATPASE ALPHA CHAIN), PROTEIN (F1-ATPASE BETA CHAIN), PROTEIN (F1-ATPASE GAMMA CHAIN), ... (8 entities in total)
• 機能のキーワード: atp synthase, fof1-atpase, oxidative phosphorylation, mitochondria, hydrolase
• 由来する生物種: Rattus norvegicus (Norway rat); 詳細
• 細胞内の位置: Mitochondrion inner membrane : P15999; Mitochondrion: P10719 P35435
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 137780.73

構造登録者

Bianchet, M.A.,Amzel, L.M. (登録日: 1998-08-06, 公開日: 1998-09-30, 最終更新日: 2024-05-22)

主引用文献

Bianchet, M.A.,Hullihen, J.,Pedersen, P.L.,Amzel, L.M.
The 2.8-A structure of rat liver F1-ATPase: configuration of a critical intermediate in ATP synthesis/hydrolysis.
Proc.Natl.Acad.Sci.USA, 95:11065-11070, 1998

PubMed Abstract: During mitochondrial ATP synthesis, F1-ATPase-the portion of the ATP synthase that contains the catalytic and regulatory nucleotide binding sites-undergoes a series of concerted conformational changes that couple proton translocation to the synthesis of the high levels of ATP required for cellular function. In the structure of the rat liver F1-ATPase, determined to 2.8-A resolution in the presence of physiological concentrations of nucleotides, all three beta subunits contain bound nucleotide and adopt similar conformations. This structure provides the missing configuration of F1 necessary to define all intermediates in the reaction pathway. Incorporation of this structure suggests a mechanism of ATP synthesis/hydrolysis in which configurations of the enzyme with three bound nucleotides play an essential role.

PubMed: 9736690
DOI: 10.1073/pnas.95.19.11065

実験手法

X-RAY DIFFRACTION (2.8 Å)