1M8E

inducible nitric oxide synthase with 7-nitroindazole bound

1M8E の概要

• エントリーDOI: 10.2210/pdb1m8e/pdb
• 関連するPDBエントリー: 1M8D 1M8H 1M8I 1M9J 1M9K 1M9M 1M9Q 1M9R 1M9T 1NOD 3NOD
• 分子名称: inducible Nitric oxide synthase, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (5 entities in total)
• 機能のキーワード: oxidoreductase
• 由来する生物種: Mus musculus (house mouse)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 102457.79

構造登録者

Rosenfeld, R.J.,Garcin, E.D.,Panda, K.,Andersson, G.,Aberg, A.,Wallace, A.V.,Stuehr, D.J.,Tainer, J.A.,Getzoff, E.D. (登録日: 2002-07-24, 公開日: 2002-08-07, 最終更新日: 2024-02-14)

• 主引用文献: Rosenfeld, R.J.,Garcin, E.D.,Panda, K.,Andersson, G.,Aberg, A.,Wallace, A.V.,Morris, G.M.,Olson, A.J.,Stuehr, D.J.,Tainer, J.A.,Getzoff, E.D.; Conformational Changes in Nitric Oxide Synthases Induced by Chlorzoxazone and Nitroindazoles: Crystallographic and Computational Analyses of Inhibitor Potency; Biochemistry, 41:13915-13925, 2002; PubMed: 12437348; DOI: 10.1021/bi026313j

実験手法

X-RAY DIFFRACTION (2.9 Å)