1M7K

Solution Structure of the SODD BAG Domain

1M7K の概要

• エントリーDOI: 10.2210/pdb1m7k/pdb
• 分子名称: Silencer of Death Domains (1 entity in total)
• 機能のキーワード: three helix bundle, chaperone
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: O95429
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 11275.77

構造登録者

Brockmann, C.,Leitner, D.,Labudde, D.,Diehl, A.,Sievert, V.,Buessow, K.,Oschkinat, H. (登録日: 2002-07-22, 公開日: 2002-08-07, 最終更新日: 2024-05-29)

主引用文献

Brockmann, C.,Leitner, D.,Labudde, D.,Diehl, A.,Sievert, V.,Buessow, K.,Kuhne, R.,Oschkinat, H.
The solution structure of the SODD BAG domain reveals additional electrostatic interactions in the HSP70 complexes of SODD subfamily BAG domains
Febs Lett., 558:101-106, 2004

PubMed Abstract: The solution structure of an N-terminally extended construct of the SODD BAG domain was determined by nuclear magnetic resonance spectroscopy. A homology model of the SODD-BAG/HSP70 complex reveals additional possible interactions that are specific for the SODD subfamily of BAG domains while the overall geometry of the complex remains the same. Relaxation rate measurements show that amino acids N358-S375 of SODD which were previously assigned to its BAG domain are not structured in our construct. The SODD BAG domain is thus indeed smaller than the homologous domain in Bag1 defining a new subfamily of BAG domains.

PubMed: 14759524
DOI: 10.1016/S0014-5793(03)01490-X

実験手法

SOLUTION NMR