1M7B

Crystal structure of Rnd3/RhoE: functional implications

1M7B の概要

• エントリーDOI: 10.2210/pdb1m7b/pdb
• 分子名称: Rnd3/RhoE small GTP-binding protein, MAGNESIUM ION, GUANOSINE-5'-TRIPHOSPHATE, ... (4 entities in total)
• 機能のキーワード: small gtpase, signaling protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Golgi apparatus membrane; Peripheral membrane protein: P61587
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 21039.59

構造登録者

Fiegen, D.,Blumenstein, L.,Stege, P.,Vetter, I.R.,Ahmadian, M.R. (登録日: 2002-07-19, 公開日: 2002-08-07, 最終更新日: 2023-10-25)

主引用文献

Fiegen, D.,Blumenstein, L.,Stege, P.,Vetter, I.R.,Ahmadian, M.R.
Crystal structure of Rnd3/RhoE: functional implications
FEBS LETT., 525:100-104, 2002

PubMed Abstract: The Rnd proteins constitute an exceptional subfamily within the Rho GTPase family. They possess extended chains at both termini and four prominent amino acid deviations causing GTPase deficiency. Herein, we report the crystal structure of the Rnd3/RhoE G-domain (amino acids 19-200) at 2.0 A resolution. This is the first GTP-structure of a Rho family member which reveals a similar fold but striking differences from RhoA concerning (i) GTPase center, (ii) charge distribution at several surface areas, (iii) C3-transferase binding site and (iv) interacting interfaces towards RhoA regulators and effectors.

PubMed: 12163169
DOI: 10.1016/S0014-5793(02)03094-6

実験手法

X-RAY DIFFRACTION (2 Å)