1M4V

Crystal structure of SET3, a superantigen-like protein from Staphylococcus aureus

1M4V の概要

• エントリーDOI: 10.2210/pdb1m4v/pdb
• 分子名称: SET3, superantigen-like protein (2 entities in total)
• 機能のキーワード: ob-fold, beta-grasp, superantigen fold, immune system
• 由来する生物種: Staphylococcus aureus
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 48429.68

構造登録者

Arcus, V.L.,Langley, R.,Proft, T.,Fraser, J.D.,Baker, E.N. (登録日: 2002-07-05, 公開日: 2002-07-17, 最終更新日: 2024-02-14)

主引用文献

Arcus, V.L.,Langley, R.,Proft, T.,Fraser, J.D.,Baker, E.N.
The three-dimensional structure of a superantigen-like protein, SET3, from a pathogenicity island of the Staphylococcus aureus genome
J.Biol.Chem., 277:32274-32281, 2002

PubMed Abstract: The staphylococcal enterotoxin-like toxins (SETs) are a family of proteins encoded within the Staphylococcus aureus genome that were identified by their similarity to the well described bacterial superantigens. The first crystal structure of a member of the SET family, SET3, has been determined to 1.9 A (R = 0.205, R(free) = 0.240) and reveals a fold characteristic of the superantigen family but with significant differences. The SET proteins are secreted at varying levels by staphylococcal isolates, and seroconversion studies of normal individuals indicate that they are strongly antigenic to humans. Recombinant SETs do not exhibit any of the properties expected of superantigens such as major histocompatibility complex class II binding or broad T-cell activation, suggesting they have an entirely different function. The fact that the whole gene family is clustered within the pathogenicity island SaIn2 of the S. aureus genome suggests that they are involved in host/pathogen interactions.

PubMed: 12082105
DOI: 10.1074/jbc.M203914200

実験手法

X-RAY DIFFRACTION (1.9 Å)