1M42

Solution structure of apoCopC from Pseudomonas syringae

1M42 の概要

• エントリーDOI: 10.2210/pdb1m42/pdb
• 分子名称: Copper resistance protein C (1 entity in total)
• 機能のキーワード: cupredoxins, copper trafficking, metal binding protein
• 由来する生物種: Pseudomonas syringae
• 細胞内の位置: Periplasm: P12376
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 10547.08

構造登録者

Arnesano, F.,Banci, L.,Bertini, I.,Thompsett, A.R. (登録日: 2002-07-02, 公開日: 2002-11-06, 最終更新日: 2024-05-22)

主引用文献

Arnesano, F.,Banci, L.,Bertini, I.,Thompsett, A.R.
Solution structure of CopC: a cupredoxin-like protein involved in copper homeostasis
Structure, 10:1337-1347, 2002

PubMed Abstract: The structure of the metal-free form of CopC, a protein involved in copper homeostasis, has been obtained. The fold is a Greek key beta barrel similar to that of functionally unrelated blue copper proteins but with important structural variations. The protein binds one equivalent of copper (II) with relatively high affinity and contains a cluster of conserved residues (His1, Glu27, Asp89, and His91) which could form a water-accessible metal binding site. The structure also reveals a loop containing the M(X)(n)M motif which is present in a number of proteins also involved in copper homeostasis. The present structure represents a link between copper-trafficking proteins and cupredoxins. Within a structural and genomic analysis, the role of CopC in copper trafficking is discussed.

PubMed: 12377120
DOI: 10.1016/S0969-2126(02)00858-4

実験手法

SOLUTION NMR