1M1C

Structure of the L-A virus

1M1C の概要

• エントリーDOI: 10.2210/pdb1m1c/pdb
• 分子名称: Major coat protein (1 entity in total)
• 機能のキーワード: dsrna virus structure; rna-protein interaction; mrna decapping; l-a virus; quai-equivalence, icosahedral virus, virus
• 由来する生物種: Saccharomyces cerevisiae virus L-A (L1)
• 細胞内の位置: Virion (Potential): P32503
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 152140.06

構造登録者

Naitow, H.,Tang, J.,Canady, M.,Wickner, R.B.,Johnson, J.E. (登録日: 2002-06-18, 公開日: 2002-10-02, 最終更新日: 2024-02-14)

主引用文献

Naitow, H.,Tang, J.,Canady, M.,Wickner, R.B.,Johnson, J.E.
L-A virus at 3.4 A resolution reveals particle architecture and mRNA decapping mechanism.
Nat.Struct.Biol., 9:725-728, 2002

PubMed Abstract: The structure of the yeast L-A virus was determined by X-ray crystallography at 3.4 A resolution. The L-A dsRNA virus is 400 A in diameter and contains a single protein shell of 60 asymmetric dimers of the coat protein, a feature common among the inner protein shells of dsRNA viruses and probably related to their unique mode of transcription and replication. The two identical subunits in each dimer are in non-equivalent environments and show substantially different conformations in specific surface regions. The L-A virus decaps cellular mRNA to efficiently translate its own uncapped mRNA. Our structure reveals a trench at the active site of the decapping reaction and suggests a role for nearby residues in the reaction.

PubMed: 12244300
DOI: 10.1038/nsb844

実験手法

X-RAY DIFFRACTION (3.5 Å)