1M13

Crystal Structure of the Human Pregane X Receptor Ligand Binding Domain in Complex with Hyperforin, a Constituent of St. John's Wort

1M13 の概要

• エントリーDOI: 10.2210/pdb1m13/pdb
• 関連するPDBエントリー: 1ILG 1ILH
• 分子名称: Orphan Nuclear Receptor PXR, 4-HYDROXY-5-ISOBUTYRYL-6-METHYL-1,3,7-TRIS-(3-METHYL-BUT-2-ENYL)-6-(4-METHYL-PENT-3-ENYL)-BICYCLO[3.3.1]NON-3-ENE-2,9-DIONE (3 entities in total)
• 機能のキーワード: nuclear receptor, ligand binding domain, protein-ligand complex, transcription
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: O75469
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 36817.65

構造登録者

Watkins, R.E.,Maglich, J.M.,Moore, L.B.,Wisely, G.B.,Noble, S.M.,Davis-Searles, P.R.,Lambert, M.H.,Kliewer, S.A.,Redinbo, M.R. (登録日: 2002-06-17, 公開日: 2003-03-04, 最終更新日: 2024-02-14)

• 主引用文献: Watkins, R.E.,Maglich, J.M.,Moore, L.B.,Wisely, G.B.,Noble, S.M.,Davis-Searles, P.R.,Lambert, M.H.,Kliewer, S.A.,Redinbo, M.R.; 2.1 A Crystal Structure of Human PXR in Complex with the St. John's Wort Compound Hyperforin; Biochemistry, 42:1430-1438, 2003; PubMed: 12578355; DOI: 10.1021/bi0268753

実験手法

X-RAY DIFFRACTION (2.15 Å)