1LPI

HEW LYSOZYME: TRP...NA CATION-PI INTERACTION

1LPI の概要

• エントリーDOI: 10.2210/pdb1lpi/pdb
• 分子名称: LYSOZYME, SODIUM ION (3 entities in total)
• 機能のキーワード: hydrolase, o-glycosyl, glycosidase
• 由来する生物種: Gallus gallus (chicken)
• 細胞内の位置: Secreted: P00698
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 14354.15

構造登録者

Wouters, J. (登録日: 1998-04-15, 公開日: 1998-06-17, 最終更新日: 2024-11-20)

主引用文献

Wouters, J.
Cation-pi (Na+-Trp) interactions in the crystal structure of tetragonal lysozyme.
Protein Sci., 7:2472-2475, 1998

PubMed Abstract: Experimental evidence of a cation-pi interaction between a sodium cation (Na+) and the indole ring of residue Trp123 in a structure (2.0 A) of hen egg-white lysozyme is presented. The geometry of the metal ion-pi interaction observed in the protein structure (distance between the aromatic plane and the cation approximately 4 A) is consistent with geometries observed among small molecules crystal structures and quantum chemistry ab initio calculations. The present crystal structure of lysozyme provides unique structural information about the geometry of binding of cations to pi systems in proteins. It shows that the metal ion-pi interaction within proteins is not significantly different from similar bindings found in small molecules and that it can be modeled by theoretical methods.

PubMed: 9828016

実験手法

X-RAY DIFFRACTION (2 Å)